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Title: Studies on epithelial cells from the human uterine cervix in monolayer tissue culture
Author: Farrell, Siobhan M.
Awarding Body: University of London
Current Institution: Imperial College London
Date of Award: 1988
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A project was designed to study a variety of aspects of cervical pathologies in an in vitro model, by light and scanning electron microscopy. This thesis describes the use of human uterine ectocervical and endocervical cell cultures in monolayer tissue culture to study the growth of vaginal pathogens; the action of antifungal drugs on fungi infected cervical cultures, the growth of neoplastic cells in culture; the possible protective effect of zinc against the growth inhibiting effect of a concentration of copper found in the uterine secretions of women using copper containing contraceptive devices. The cultures were innoculated with vaginal isolates of fungus. Candida albicans, Candida krusei, Candida tropicalis, Torulopsis glabrata and Saccharomyces cerevisiae and their growth on the cultures was described by a scanning electron microscopy study. Three stages of infection were described for Candida albicans. These were the attachment of yeast cells, the growth of germ tubes and the invasion of epithelial cells by hyphae.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available