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Title: The behavioural and neural effects of TDCS
Author: Soyoung, Kim
ISNI:       0000 0004 6352 985X
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2016
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Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is known to modulate cortical excitability in a polarity specific manner and influence motor learning and memory. The current thesis work investigated the behavioural effects of tDCS on motor learning using the force adaptation and deadaptation task. The results revealed the timing dependent effects of tDCS that anodal tDCS applied to the primary motor cortex (M1) before or after the adaptation phase disturbed the motor memory retention. The neural effects of tDCS were also studied using various neuroscience techniques. The neurochemical changes induced by tDCS were investigated using magnetic resonance spectroscopy (MRS). It was found that anodal Ml tDCS can reduce GABA levels in Ml. Importantly, the extents of the reduction in GABA levels could predict the inter-individual difference in the force adaptation and deadaptation performance. The changes in the brain oscillatory activity was investigated using magnetoencephalography (MEG), but no significant difference was found between the anodal or cathodal Ml and sham condition in the movement-related motor cortex brain oscillatory activity. The electrophysiological changes were investigated using transcranial magnetic stimulation (TMS), and the evidence of facilitatory effects of anodal M1 tDCS was observed in the motor threshold (MT), and the evidence of inhibitory effects of cathodal M1 tDCS was observed in the TMS measure of short-interval intracortical inhibition (SICI). For the better understanding of the relationship between various neural measures, the correlation analyses were conducted. No robust relationship was found between MEG measures of movement-related motor cortex brain oscillatory activity and MRS measures of GABA levels. The correlation analysis of MRS and TMS measures revealed that individuals’ baseline MRS-measured GABA concentration levels are correlated with TMS measure of early phase SICI.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available