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Title: Inflammation of white adipose tissue in obesity
Author: Ghaith, Mazen Mohammedsaeed
ISNI:       0000 0004 6352 9665
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2016
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Obesity is now recognized as an inflammatory disease, in which white adipose tissue (WAT) is an active site and major contributor to this manifestation. The work in this thesis was directed towards the notion of adipose tissue inflammation in obesity and examined whether low oxygen tension or “hypoxia” may underpin this phenomenon. All experiments in this thesis looked at aspects related to adipose tissue biology, function, regulation and inflammation from the molecular level to the cellular and/or physiological level; with either human adipose biopsies or primary culture of cells isolated from fresh adipose biopsies of human or rat origin. These experiments included; A human study investigating the potential beneficial effects of naturally occurring citrus flavonoids on insulin sensitivity and inflammatory phenotype of subcutaneous adipose tissue (SAT) in overweight and/or obese women (BMI 27-35), who had mild features of insulin resistance, but were otherwise healthy. This involved comprehensive gene expression profiling of selected genes of interest related to adipose tissue function, inflammation and insulin sensitivity using TaqMan low density array technology. It was found that although SAT was associated with a noticeable expression of inflammatory markers, frequent consumption of orange juice (250 ml/day) rich in flavonoid compounds (686.85 mg/L hesperidin and 55.93 mg/L narirutin) was not associated with any significant alterations in these transcripts. In addition, supplementation of the diet with an extra 22.5g of sugars derived from the orange juice did not have any detrimental effects in serum uric acids, plasma lipid, insulin sensitivity and inflammatory markers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available