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Title: Lung infection in cystic fibrosis
Author: Hurley, Matthew
ISNI:       0000 0004 6352 0265
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2016
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Cystic fibrosis (CF) is characterised by viscid secretions that, in the lungs, pre-dispose to infection. Many people with CF experience 'pulmonary exacerbations' accompanied by intermittent deteriorations in lung function. Pulmonary exacerbations are associated with a more rapid decline in lung health over time and are associated with infection. Early infection managed aggressively may be successfully eradicated. With successive infections and cumulative lung damage, chronic infection is established. Chronic infection leads to progressive decline in lung function with associated reductions in quality of life and increased treatment burden, morbidity and mortality. Naturally antibiotic-tolerant organisms that evolve resistance to commonly used antibiotics are problematic, in particular Pseudomonas aeruginosa. As is the case with other organisms that cause lung infection in those with CF, P. aeruginosa's antibiotic tolerance and ability to establish chronic infection is thought to be conferred through the biofilm mode of growth. The adaptability of the organism to pressures exerted by antibiotics and competition within the lung environment promote antibiotic resistance. New strategies effective in preventing and managing chronic infection are likely to yield improvement in survival and quality of life, however the development of such agents is yet to materialise.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available