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Title: Design, synthesis and biological evaluation of highly selective CDK9 inhibitors for cancer treatment
Author: Shao, Hao
ISNI:       0000 0004 6351 421X
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2014
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Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases, such as cancer, inflammatory and cardiac hypertrophy. Although a number of CDK inhibitors have been identified and taken into clinical trials, all show inhibitory activity against several CDKs and other kinases. The current lack of selective CDK9 inhibitors is limiting efforts to fully understand and validate CDK9 as a drug target. This project aimed to design and synthesize a novel class of 2,4,5-tri-substituted pyrimidine compounds as highly selective CDK9 inhibitors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available