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Title: The epidemiology of systemic lupus erythematosus in the UK : can earlier diagnosis be achieved?
Author: Rees, Frances
ISNI:       0000 0004 6351 3639
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2016
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Systemic lupus erythematosus (SLE) is a rare chronic autoimmune disease which can affect any organ in the body. It can vary from a mild to a life-threatening illness. The most recent studies of the number of people in the UK with SLE were from the 1990s. These estimated that SLE affected approximately 4 in 10,000 people and suggested that this number might be increasing. Symptoms can be diverse and include rashes, arthritis and pleurisy. Due to this variation it can be difficult to diagnose in the early stages and as a result diagnosis can be delayed. A UK survey found a mean delay in diagnosis of 7.7 years. Diagnosing people with SLE earlier could prevent long-term organ damage, reduce the need for long-term treatments such as dialysis and improve survival and quality of life. The first aim of this thesis was to describe trends in the epidemiology of SLE in the UK (incidence, prevalence, mortality and morbidity) for the last decade (1999-2012) and examine how this varied with gender, age, ethnic group and region of the UK. The second aim was to examine consultation behaviour in primary care prior to SLE diagnosis to identify key clinical features or consultation patterns which could enable earlier diagnosis of SLE and to develop and validate a risk prediction model to assist this.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available