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Title: The effect of exercise on oxidative stress and other health markers : exploring new technology and methodology
Author: Rai, Sahara
ISNI:       0000 0004 6347 0552
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2017
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Taking part in regular physical activity leads to adaptive response that enables the body’s antioxidant defence to be better equipped to fight against oxidative stress. Exercise intensity seems to be one of key factors that determines the effectiveness of exercise. The work presented in this thesis used novel approaches, through the application of emerging technologies, to study physical activity and its effects. This thesis contributes to the existing literature by being the first to investigate the effect of exercise on a marker of oxidative stress in the brain, an organ that becomes impaired (including oxidative damage) with ageing and diseases associated with ageing. The finding from this thesis suggests that brain glutathione (GSH) of young sedentary men as measured by magnetic resonance spectroscopy (MRS) was altered in response to acute exercise, in an exercise intensity dependent manner. Observed changes in peripheral markers of oxidative stress were also exercise intensity dependent. The brain seems to be protected against hyperperfusion injury during high intensity phase of high intensity interval exercise. Objectively measured physical activity levels were not significantly increased by an unsupervised home-based exercise intervention in older adults, potentially due to a lack of progressive goals based on adherence to physical activity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QH301 Biology ; QP Physiology ; RC1200 Sports Medicine