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Title: Outcomes of laparoscopic fundoplication
Author: Khan, Mansoor Ali
ISNI:       0000 0004 6350 7503
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2016
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Gastro-esophageal reflux disease (GORD) is common and a variety of surgical repair techniques have been shown to be effective. This thesis contains two randomised controlled trials and a combined data analysis of both studies to establish which techniques appear the most effective in controlling reflux. It also contains a pilot study to determine whether intraoperative manometry can predict which patients are likely to suffer from postoperative dysphagia. One hundred and three underwent partial fundoplication (Anterior or Posterior) and one hundred and twenty one patients underwent total/subtotal (Nissen or Lind) in the randomised controlled trials and 40 patients were recruited into the intraoperative manometry study. Patients were followed up for 12 months and their change in symptoms recorded. In the partial fundoplication trial, patients who underwent posterior fundoplication had better control of symptoms compared to those who underwent anterior fundoplication at the 12 month follow up point. There was no difference between the groups who underwent Nissen and Lind fundoplication. When the studies were collated, the laparoscopic total/subtotal fundoplication appears to be superior in the control of reflux when compared to the laparoscopic partial fundoplication. Intraoperative manometry may be advantageous as the study does suggest that this investigation may be useful in predicting post-operative dysphagia.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC Internal medicine