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Title: Optical coherence tomography imaging and quantification of corneal inflammation
Author: Konstantopoulos, Aristides
ISNI:       0000 0004 6348 9157
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2016
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Infection and inflammation of the cornea are common clinical presentations that are potentially blinding. Evaluation of the presenting condition and assessment of the treatment response are subjective and rely greatly on examiner experience. In-vivo quantification of the extent of ocular surface inflammation could lead to objective criteria for diagnosis and monitoring of infective and inflammatory conditions of the cornea. It could also transform research on the treatment or prevention of these conditions. In this thesis, the capabilities of Anterior Segment Optical Coherence Tomography (AS-OCT) as an imaging and quantification modality in ocular surface inflammation and infection are investigated. AS-OCT is applied to research on prevention, diagnosis and monitoring of bacterial keratitis; the invivo quantification findings are verified with laboratory investigations, including cytokine quantification, immunohistochemistry and bacterial counts. This work has shown that a range of AS-OCT parameters, including corneal thickness, infiltrate thickness and infiltrate width, can be used for quantitative objective assessment of patients with bacterial keratitis. Greater corneal parameters of acute inflammation in Gram-ve compared to Gram+ve infection at presentation, specifically corneal thickness and infiltrate thickness, are indicative of Gram-ve keratitis. A reduction in these AS-OCT parameters between presentation and day 3 of treatment is identified as a criterion that indicates a successful treatment response. Finally, AS-OCT quantification of acute corneal inflammation in an animal study has shown that current bacterial keratitis prophylaxis strategies following keratoprosthesis surgery may not be effective.
Supervisor: Hossain, Parwez ; Lotery, Andrew ; Mehta, Jodhbir Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available