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Title: Systemic inflammation and sickness behaviour in Alzheimer's disease
Author: Butchart, Joseph William
ISNI:       0000 0004 6348 8955
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2016
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Alzheimer's disease is the commonest cause of dementia in the UK. Inflammatory processes play a role in the pathology of the disease, and may trigger pathological neuroimmune sickness behaviour, manifesting as behavioural and psychological symptoms. This thesis explores the influence of systemic inflammation on brain inflammation, neuroimmune sickness behaviour and disease progression in Alzheimer's disease. First, I describe a study that examined the influence of age-related endocrine dyscrasia on systemic inflammation in Alzheimer's disease. Data are presented to demonstrate a relationship between altered hormonal status and systemic Tumour Necrosis Factor-alpha in men with Alzheimer's disease. Second, I describe the construction of a scale to measure pathological neuroimmune sickness behaviour in people living with Alzheimer's disease. Data are presented for the reliability and validity of the resulting Sickness Behaviour Scale in a construction cohort and an independent validation cohort. Third, I present a randomized, placebo-controlled, double-blind, clinical trial on the safety, tolerability and efficacy of the anti-inflammatory drug etanercept in Alzheimer's disease. Etanercept was safe, well-tolerated and significantly reduced behavioural, functional and cognitive decline in Alzheimer's disease.
Supervisor: Holmes, Clive ; Nicoll, James Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available