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Title: The dynamics of skeletal muscle metabolism, oxygenation, and fatigue during high-intensity exercise in humans
Author: Cannon, Daniel Timothy
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2012
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Exercise tolerance is a key determinant of mortality risk and quality of life. While the public health impact of poor exercise tolerance is now well known, the mechanisms which underpin intolerance are largely uncertain. The purpose of this thesis was to investigate the cascade of events that bring about systems limits during high-intensity work. During constant work rate exercise above the lactate threshold (LT), the kinetics of oxygen uptake (V02) are supplemented by a VO2 slow component (202 ) which reduces work efficiency. It has been postulated that this reduction in efficiency is due to progressive fatigue and motor unit recruitment. We, therefore, characterised changes in the power-velocity relationship during sub- and supra-LT cycle ergometry in concert with VO2 kinetics. Velocity-specific peak power was significantly reduced (p < 0.05) by 3 min of heavy (-103 ± 46 W) and very-heavy exercise (-216 ± 60 W), with no further change by 8 min. These results suggested that muscle fatigue is requisite for the VO2sc. However, the maintenance of velocity-specific peak power between 3 and 8 min suggests that progressive muscle recruitment is not obligatory.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available