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Title: A synthetic study of febrifugine and isofebrifugine analogues towards novel drug candidates
Author: Mbelesi, Nomagugu
ISNI:       0000 0004 6350 3377
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2016
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Febrifugine and Isofebrifugine are alkaloids isolated from Dichroa febrifuga Lour and have been characterised to be active against malaria. However, as there is still some ambiguity surrounding isofebrifugine's structure, febrifugine has generated a greater interest in the medicinal chemistry community as a lead compound for synthesising a new wave of antimalarial drugs. For example halofuginone is the synthetic derivative of febrifugine and has recently shown higher activity against malaria than that observed for the parent alkaloid. Through extensive work, the development of new hybrid molecules containing features associated with febrifugine were investigated. This required efficient routes towards these analogues to be devised. Indeed, the synthesis of the non-commercially available halofuginone quinazolinone was accomplished, permitting a route for the production of novel halofuginone analogues. In addition X-ray crystallisation data was obtained for the natural febrifugine analogue and its synthetic derivative epifebrifuginol.
Supervisor: Harrity, Joseph Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available