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Title: The effect of fluoride glass slow-release devices on the protection of primary and permanent dental enamel to erosive challenge
Author: Kotantoula, Gioula
ISNI:       0000 0004 6349 751X
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2016
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Aim: To investigate the use of fluoride glass slow-release devices (FGSRD) for the prevention of dental erosion of human dental enamel in vitro. Methods: Human teeth (permanent and primary) were used for this study. Enamel slabs were randomly allocated to four study groups: Group 1: 24 permanent enamel slabs with FGSRD, Group 2: 24 permanent enamel slabs with placebo non-FGSRD, Group 3: 20 primary enamel slabs with FGSRD, Group 4: 20 primary enamel slabs with placebo non-FGSRD. The glass slow-release devices were randomised into two groups. Test and placebo groups were coded until the end of the study. The enamel slabs were dipped in a citric acid solution for two minutes five times daily for 28 days and brushed twice a day. This was to create the erosive environment for this in vitro study. The slabs were kept in artificial saliva and stored in an incubator at 37°C. The glass slow-release devices (fluoride and non-fluoride) were present in all containers. The surface profile was measured at baseline using surface profilometry and after 14 and 28 days of the cycling regime. Analysis: Simple t-tests were used to compare the permanent and primary teeth groups with 0.05 as the significance level and an ANOVA t-test with a Bonferroni correction to compare: primary and permanent teeth. Daily fluoride release of the FGSRD’s was measured. Results: For enamel of primary teeth, after 14 days 40% less erosion was observed in the F group which decreased to 31% at the end of the study period, i.e., 28 days. This was highly statistically significant (p < 0.001) at both time points. For permanent enamel, no significant differences were observed (p=0.091). Conclusion: FGSRD’s have great potential for protection of primary human enamel against erosive challenge in addition to a number of other uses.
Supervisor: Toumba, Kyriakos Jack ; Duggal, Monty S. ; Malinowski, Marina Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psy.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available