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Title: Phytochemical composition and antimicrobial properties of four plants indicated for traditional medicine use
Author: Al-Dulaimi, Omar Ahmed Abass
ISNI:       0000 0004 6348 7821
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 2017
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The rapid development of seriously drug-resistant pathogen strains has created a dangerous problem to public health. The discovery of new effective antimicrobials remains an urgent task to control microbial resistance. Natural products can offer special stereochemistry and unlimited diversity of natural leads which are biologically active or ready for development and structure optimization strategies. Four medicinal plants Cylicodiscus gabunensis (CG), Pogostemon cablin (PC), Perilla frutescens (PF) and Magnolia biondii (MB) were selected for investigation of their phytochemical composition and antiplasmodial and/or antibacterial properties. A bioassay guided fractionation method has been followed to characterize the antiplasmodial and antibacterial constituents of CG. Flash column chromatography and preparative HPLC were used to obtain the bioactive compounds. GC-MS, LC-MS, and NMR have been used for chemical analysis purposes. For evaluation of the antibacterial activity, disk diffusion assay, alamar blue microplate assay, time kill kinetic and scanning electron microscopy (SEM) methods have been used. The work led to the isolation of the most potent antiplasmodial fraction of CG with IC50 of 4.7.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RV Botanic ; Thomsonian ; and eclectic medicine