Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711693 |
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Title: | New transformations of azacycles | ||||||
Author: | Mortimer, Claire |
ISNI:
0000 0004 6060 3145
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Awarding Body: | University of Oxford | ||||||
Current Institution: | University of Oxford | ||||||
Date of Award: | 2015 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
The work presented in this thesis involves new transformations of azacycles, focusing on the introduction of functionality α-to N. α-C-H functionalisation on an azetidine has been a long-standing challenge, with N-protecting/activating groups that work well in the higher and lower azacyclic systems not viable. A recent breakthrough in the Hodgson group showed the rarely used N-thiopivaloyl group was effective for α-deprotonationâ electrophile trapping on azetidines, but was not without limitations concerning harsh removal conditions and scope for further substitutions. This thesis describes efforts to overcome these issues by development of a new protecting/activating group for N, t-butoxythiocarbonyl (Botc).
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Supervisor: | Hodgson, David | Sponsor: | Engineering and Physical Sciences Research Council | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.711693 | DOI: | Not available | ||||
Keywords: | Azetidine ; Lithiation ; Asymmetric synthesis ; Chemistry, Organic ; Organolithium compounds ; Heterocyclic chemistry ; Azacycles ; Heterocycles ; Organic chemistry ; Organolithium | ||||||
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