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Title: Transport phenomena in the foetal gastric mucosa
Author: Kendall, Anne
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 1968
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An outline of the history of gastric electrolyte physiology has been presented along with the development of general electrolyte physiology and these have been related to foetal gastric physiology. An outline of the present knowledge of A.T.P. and its formation and utilization related to carbohydrate metabolism, has been given. By using isotopic tracers, 70% of the total short-circuit current has been found to be due to the active transport of sodium from mucosa to serosa. The relationship between the sodium independent fraction and the net chloride flux from serosa to mucosa in the foetal rabbit stomach, has been demonstrated by the use of isotopic tracers, and the latter found to be 166% of the former. The metabolic dependence of both the sodium and the sodium independent current of the foetal rabbit stomach has been studied with their relationship to the normal functioning of the oxidative phosphorylation chain and the anaerobic glycolytic cycle, by the use of various inhibitors of the metabolic cycle. An A.T.P.-ase has been isolated from the foetal gastric mucosa and its activity studied in relation to the active transport of sodium and hydrochloric acid. No specific relationship was shown to exist. It is concluded from these results that the sodium current is most probably maintained by energy derived from the hydrolysis of A.T.P., though adequate oxygenation is required for maximum activity; and that the sodium independent current seems to be wholly dependent on the presence of oxygen, provided of course, that some energy source, such as glucose, be present. The significance of these results has been discussed with regard to foetal physiology, and to the secretion of acid. A comparison between foetal and adult gastric physiology has been made.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Physiology