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Title: 31 published papers on the amino acid composition and titration curve of collagen
Author: Bowes, Joane H.
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 1958
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The amino-acid composition of gelatin has been extensively studied, but until recently little attention has been paid to that of its precursor collagen, the natural protein of skin. Some of the analyses of collagen which have been reported were carried out by methods which are now considered unsatisfactory, and in no case have most of the major component amino-acids been determined in one sample of the protein. Further, most of the analyses have been made on coUagens which had been given an alkaline or enzyme treatment, or both, to remove the keratins, elastic fibres and reticular tissue which occur in close association with it, and there is a risk that such treatments will cause some modification of the collagen. For the present study, a sample of collagen has been prepared with the minimum of chemical treatment, since it was considered that the presence of small amounts of elastic fibres and reticular tissue would lead to less error than the treatments necessary to bring about their removal. Also, it seems doubtful whether it is possible to remove these proteins completely by any of the methods which have been suggested.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry