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Title: A contribution to the chemistry of antimalarials
Author: Hall, Dorothy Muriel
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 1943
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The aim of the present investigation was to obtain more information as to the relation between constitution (extended in the sense of configuration in certain instances) and anti-malarial activity in the acridine series and to prepare derivatives of other ring systems, which had not previously been tested for antimalarial activity. Two bases which may resemble 2-amino-5-diethylamino-pentane in configuration were considered for condensations with 5-chloroacridines. The first, o-aminobenzyldiethylamine (I), was prepared by reduction of the nitro compound, obtained by the condensation of o-nitrobenzyl chloride with die thylamine. Four syntheses of the second base, 2-aminocyclohexyldiethylamine (II), were attempted but all were unsuccessful [diagram]. A third base, (3-diethylaminoethylamine, was prepared by the reduction of diethylamino-acetonitrile. 5-Chloroacridine (III) and 2:5-dichlero-7-methoxyacridine (IV) were prepared from the corresponding diphenylamine-2-carboxylio acids and 1:5-dichlero-9-methylacrldine (V) from the corresponding acridone.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Chemistry