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Title: Preparation of anti-malarial compounds
Author: Lockhart, Diana
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 1935
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The quinine molecule has been decomposed giving Pyridine and quinoline derivatives. Compounds having two discrete basic centres and a methoxy group show pharmacological activity. These considerations led to the choice of Lepidines and quinaldines as likely starting points from which to prepare derivatives having drug motion. Furthermore such molecules have a methyl group - 1CH3/C - which, situated as it is with respect to the nitrogen in the ring, should be reactive. For the same reason substitution in the 2- and 4- positions should give reactive compounds with which to work. Quinoxalines and Pyrimidines are examples of such compounds; they were also investigated in order to produce additional evidence of this reactivity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Pharmacology