Use this URL to cite or link to this record in EThOS:
Title: Polymethacrylate based hybrids for bone regeneration through controlled polymerisation
Author: Chung, Justin
ISNI:       0000 0004 6059 1906
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2015
Availability of Full Text:
Access from EThOS:
Access from Institution:
When bone is fractured, plaster cast or metal plate is needed to hold it in a proper position to allow self-healing. However, when the fracture is above a critical defect size, bone cannot regenerate itself. Biomimetic material that can aid bone regeneration and acts as a temporary template would be an ideal solution. However, there are no biomaterials that can fulfil all the criteria as a bone substitute. Bioglass is one of the bioactive ceramics that can bond with host bone and stimulate bone regeneration, and is known to be more bioactive than other competing bioceramics. However, all bioactive ceramics are too brittle to be used in load bearing sites. Hybrids have the potential to overcome this problem because their nano-scale interaction of organic polymer and silica network can provide more promising physical properties. Particularly, past researches have introduced various copolymers of polymethacrylates as an organic source to take advantage of their self-hardening mechanical property. However, all the polymers were not well-defined to produce bespoke hybrids. In this thesis, copolymers of methyl methacrylate and 3-(trimethoxysilyl)propyl methacrylate were synthesised through reversible-addition fragmentation and group transfer polymerisation techniques to produce well-defined polymers. In addition, different polymer architectures of linear, randomly branched, and star were synthesised and introduced to class II hybrids via the sol-gel process. The hybrids were able outperform bioactive glass and hybrids from previous studies in terms of mechanical properties. In addition, bone forming cells were able to adhere and proliferate on the hybrids. To improve flexibility of the hybrids, n-butyl methacrylate based star polymer was investigated as an alternative to the copolymers of methyl methacrylate. Butyl methacrylate based hybrid was able to meet the mechanical properties of trabecular bone.
Supervisor: Jones, Julian Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral