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Title: Surface evaluation of enamel and dentine in toothwear and dentine hypersensitivity
Author: Seong, Joon
ISNI:       0000 0004 6059 0276
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2016
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Toothwear is a growing problem in both children and adults. This is predominantly due to increasing numbers of population maintaining their natural dentition longer and an increase in the intake of dietary acids. Toothwear can lead to poor aesthetics and may result in dentine hypersensitivity, a painful condition that can affect quality of life. This dissertation determined if in vivo replica impression methodologies were able to detect early toothwear and its subsequent repair, and dentine tubule occlusion for the assessment of dentine hypersensitivity. The first two clinical studies explored the concept of using replica techniques to develop an accurate method of quantifying the degree of dentine tubule occlusion in vivo and correlating this with clinical pain score. Technical issues encountered in the first study were overcome, at least in part, and in the second study it was demonstrated that the replica technique had utility for tracking tubule patency over time with significant differences between the groups treated with strontium acetate (occluding) and a fluoride (non-occluding) toothpaste observed. In the third study, in vitro experiments demonstrated the ability of the replica technique to accurately reproduce early stage enamel erosion and a scale to quantify this was developed. Using this scale, changes in the surface characteristics of enamel following the consumption of acid drinks and its subsequent repair over 24 hours were detected in vivo. The fourth clinical study, introduced a calcium sodiumphoshosilicate/fluoride toothpaste aiming to protect the enamel surface from acid challenge with evidence of faster repair of the surface compared to a water only control. Taken together these studies demonstrate the utility of the replica technique for investigating clinical outcomes following the application of products designed to prevent or treat erosive toothwear and dentine hypersensitivity, although further work to refine the technique is required.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available