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Title: Molecular and life-course aspects of APOE in cognition
Author: Sinclair, Lindsey Isla
ISNI:       0000 0004 5994 417X
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2016
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Dementia has a devastating effect on patients and those around them. Alzheimer's disease (AD) is the most common form of dementia. There is no cure and the prevalence may increase as much as fourfold by 2050. Variation in the APOE gene is the best-known genetic risk factor for AD. There is evidence to suggest that changes are evident in those with the high-risk Ɛ4 variant decades before AD develops. The exact nature of these changes, timing and their effect on brain structure and function is not clear. Another variant, the Ɛ2 variant seems to protect against AD but again the mechanism is unclear.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available