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Title: Effects of ginger drink on risk markers of cardiovascular disease in male participants
Author: Ukeyima, Moses Terkula
ISNI:       0000 0004 5992 5796
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2016
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Chronic consumption of fresh ginger rhizome or ginger powder has been reported to exert hypoglycaemic, hypolipidaemic, and systemic antioxidant effects in humans. Hypotensive and vasodilatory effects of ginger have also been reported in vivo. However, the effects of acute ginger consumption on postprandial blood pressure, vascular function and cardio metabolic risk markers in men with less than 10 % cardiovascular disease (CVD) risk have not previously been studied. Initially, various commercial ginger preparations were analysed for their 6-, 8-gingerol and 6-shogaol content using high performance liquid chromatography (HPLC). Following this, a randomized, controlled, single blinded cross over study was conducted with 22 men with mean age of 49 years and BMI of26.9 kg/m2 Participants consumed 300ml of standardized aqueous ginger beverage (selected after analysis above) containing 15.36 mg 6-gingerol, 8.85 mg 8-gingerol and 1.41 mg 6- shogaol or control (water) along with a high fat breakfast and high carbohydrate lunch and various cardio-metabolic outcomes were assessed. There was a trend towards a postprandial reduction in both systolic and diastolic BP after the consumption of ginger, although these effects did not achieve significance (P>O.05). Similarly, there were no significant impacts of ginger intake on the postprandial FMD response, which was depressed by the high fat meal challenge, as well as no significant improvement in Aix or plasma and urinary NOx. There was also no significant impact of ginger intake on postprandial responses of plasma lipids and glucose to the high fat meal regime. However, ginger intake was observed to significantly modulate the plasma antioxidant capacity. In conclusion, the acute consumption of a standardized ginger beverage did not significantly improve postprandial SBP, DBP and FMD.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available