This thesis focuses on the creative work of Edgar Allan Poe, and pieces together how various references to music in his poems and tales function in ways that echo throughout his oeuvre. By taking into account the plots and themes that surround references to music in Poe’s works, this thesis explores how Poe uses and describes music as it inhabits real world settings, liminal spaces, and otherworldly sites. The literature this thesis draws from ranges from tales little-discussed in Poe criticism, such as “The Spectacles” and “The System of Doctor Tarr and Professor Fether,” to more complex and popular tales such as “The Fall of the House of Usher” and “The Masque of the Red Death”; the same is true of the poems, which range from “Fanny” to “Annabel Lee.” The exploration of the less critically popular texts in conjunction with the more critically popular ones brings to light a clear hierarchy of music’s function in the tales and poems of Edgar Poe in ways that converse with his treatment of madness and the divine. The work of music and literature scholars will serve as the basis for distinguishing and historically positioning Poe’s use of certain musical terms, as well as ultimately providing a means to express the mythical, philosophical, and theological implications of music’s place in Poe’s works.