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Title: Exploring the fractionation of autism spectrum disorder at the cognitive level
Author: Brunsdon, Victoria Elizabeth Anne
ISNI:       0000 0004 5991 3189
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2016
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The behavioural symptoms of autism spectrum disorder (ASD) are thought to reflect underlying cognitive deficits/differences. Single cognitive deficit models of ASD have attempted to reduce the varied behavioural symptoms of the disorder to a single underlying cognitive deficit. However, there is a need to move on from these single cognitive deficit accounts of ASD. Therefore, the main focus of the thesis is to explore the potential for a multiple cognitive model of ASD using the predictions of the fractionated triad account. The data that is examined in the thesis originated from the Twins Early Development Study (TEDS) where one or both children met diagnostic criteria for ASD. A subsample of adolescents took part in the Social Relationship (SR) study. Overall, 181 adolescents with a diagnosis of ASD and 73 unaffected co-twins were included in the SR sample, plus an additional 160 comparison control participants. The findings in this thesis do not support a strong version of the fractionated account of ASD, in which distinct causes at the genetic and neural levels relate to distinct deficits at the cognitive level, and are associated with distinct symptoms of ASD at the behavioural level. There were some selective relationships between cognitive atypicalities and the behavioural symptoms of ASD, but these differed depending on the diagnostic symptom measure used. A weaker version of the fractionated theory is supported in which multiple cognitive deficits characterise ASD, and these cognitive deficits relate to distinct symptoms, as in the strong version, but a single cognitive deficit can explain more than one symptom domain, and more than one cognitive deficit can explain a single symptom domain. General interpretations are discussed using the framework of the fractionated triad theory of ASD. The limitations of the current thesis and potential future research are also considered.
Supervisor: Happe, Francesca Gabrielle Elizabeth Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available