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Title: Immunohistochemical and genomic analysis of ductal carcinoma in situ of the human breast
Author: Brown, John Peter
ISNI:       0000 0004 5991 2995
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2016
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Ductal Carcinoma in Situ (DCIS) is a non obligate precursor of invasive breast cancer. Due mainly to improved screening methods the detection of DCIS has risen over the last twenty years. The inability to reliably predict progression to invasive breast cancer results in the possible overtreatment of what can be regarded as a non-life threatening condition. Current treatment options remain controversial with no consensus upon the choice of mastectomy or breast conserving surgery with or without radiotherapy or adjuvant hormone therapies. The natural progression and molecular pathology of DCIS also still remains poorly understood. Examination of DCIS cases with known clinical outcome has been carried out using traditional pathological criteria, immunohistochemistry and genomic analysis. Tissue microarrays have been constructed and stained with a panel of antibody markers demonstrating the presence of molecular subtypes of DCIS similar to those found in invasive breast disease, although at different frequencies. Molecular inversion probe arrays have revealed a complex heterogeneity exists in early stages of breast cancer that may be drivers of invasion. Comparison with invasive breast disease and with DCIS associated with invasive breast disease reveals a highly complex system, where progression may rely on genomic changes already established within pure DCIS or those that occur during the DCIS phase of tumourigenesis.
Supervisor: Gillett, Cheryl Elaine ; Pinder, Sarah Elizabeth Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available