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Title: Laser speckle contrast detection of acoustic radiation force response
Author: Li, Sinan
ISNI:       0000 0004 5917 7134
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2016
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Light and ultrasound are both non-ionizing radiations, ideal for biomedical applications. Recent studies on combining ultrasound and light for biomedical imaging show new promises in improving imaging quality and/or providing complementary imaging contrast. Among a variety of the imaging modalities that simultaneously use ultrasound and light, this work focuses on optical detection of tissue responses to acoustic radiation force (ARF). The applications include optical shear wave elastography and ultrasound modulated optical tomography. The first half of the thesis provides a systematic study on tracking shear waves in optical turbid media using CCD-based laser speckle contrast analysis. The theory, simulation and experiment are developed and cross-validated. The simulation quantitatively relates CCD speckle contrast signal with shear waves, providing useful information to understand the underlying physics. In addition, multiple shear waves are tracked using laser speckle contrast detection. Results show that two counter-propagating shear waves produce a modulation pattern in the optical signal, and the modulation pattern was suggested by simulation as a result of the dual shear wave interference. Shear wave speed measurements in phantoms suggest that the dual shear wave approach is more accurate than the single shear wave approach as that the standard deviation of the speed measurement is reduced by a factor of at least 2. The the dual shear wave approach also provides a reduced boundary effect. Both factors suggest that the dual shear wave approach should improve the accuracy of elasticity measurements. In the second half of the thesis, instead of detecting ARF response in the late phase, the study is motivated by detecting ARF response in the early stage for enhancement of ultrasound modulation of light. A pilot study on incorporating perfluorocarbon-based phase change contrast agent with ultrasound modulated optical tomography is explored. To understand the phase transition process, a quantitative measurement of acoustic nanodroplet vapourisation is developed. A preliminary result also showed that a single ultrasound burst can simultaneously vaporise the nanodroplets and sonify the converted microbubbles to provide additional ultrasound modulation of light. This additional light modulation was shown to increase the laser speckle contrast signal detected on a CCD camera.
Supervisor: Tang, Meng-Xing ; Elson, Daniel S. Sponsor: Engineering and Physical Sciences Research Council ; Imperial College London
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral