This dissertation aims to study the reception of the Latin poet Horace in the Italian Renaissance, taking into consideration works composed in several different genres both in Latin and Italian vernacular between 1498 and 1600. This thesis follows five main pathways of investigation: 1) to study the Renaissance biographies of the poet; 2) to analyse several exegetical works both in Horace’s single texts and his whole corpus; 3) to study the Italian translations written both in prose and verse which were made during the Cinquecento; 4) to study in depth those who imitated Horace in their lyrical and satirical poems composed in Italian; and 5) to examine those Neo-Latin poetical works (mainly pertaining to the lyrical and satirical genres). This dissertation points out that the numerous and various forms of Horatian reception help to evaluate the real flourishing of sixteenth-century interest in the Latin poet, interest that reflects the fact that Horace was part of the new Renaissance canon of classical authorities. Within the sixteenth-century conflict of cultures, Horace appears as one of the main protagonists of the critical and literary scenes, as is shown by the attention that his works received from the point of view of editions, commentaries, and translations respectively, as well as by the fact that his texts were placed at the centre of several literary imitative practices, his example being able to offer the Renaissance one important basis upon which to found part of its new culture. Indeed, Horace allowed the emergence of an ethical strain to the Renaissance lyric, as well as contributing to the provision of rules for sixteenth-century literary criticism.