Use this URL to cite or link to this record in EThOS:
Title: Robust oscillations in cells
Author: Todd, Thomas
ISNI:       0000 0004 5917 1816
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Oscillating chemical signals in cells play an essential role in biological processes. Understanding how to produce reliable oscillators using cellular machinery is useful for genetic engineering and is a key goal of synthetic biology. Motivated by an analysis of the robustness of a biological oscillator found in the cell cycle, a new technique is developed to evaluate the robustness of nonlinear models of oscillating genetic networks. This technique has been embedded in a software framework called INTRON which can be used by biologists seeking to design robust genetic oscillators or to understand the robustness of existing models. A set of case studies are presented in which INTRON is used to analyse the robustness of genetic oscillators.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available