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Title: Robust oscillations in cells
Author: Todd, Thomas
ISNI:       0000 0004 5917 1816
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2015
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Oscillating chemical signals in cells play an essential role in biological processes. Understanding how to produce reliable oscillators using cellular machinery is useful for genetic engineering and is a key goal of synthetic biology. Motivated by an analysis of the robustness of a biological oscillator found in the cell cycle, a new technique is developed to evaluate the robustness of nonlinear models of oscillating genetic networks. This technique has been embedded in a software framework called INTRON which can be used by biologists seeking to design robust genetic oscillators or to understand the robustness of existing models. A set of case studies are presented in which INTRON is used to analyse the robustness of genetic oscillators.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available