Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685333 |
![]() |
|||||
Title: | Structure elucidation of the kalimantacin antibiotics | ||||
Author: | Thistlethwaite, Iain R. G. |
ISNI:
0000 0004 5914 6370
|
|||
Awarding Body: | University of Bristol | ||||
Current Institution: | University of Bristol | ||||
Date of Award: | 2015 | ||||
Availability of Full Text: |
|
||||
Abstract: | |||||
In this thesis the production, isolation and purification of the kalimantacin antibiotics are
described along with details of the elucidation of the structures including the relative and
absolute stereochemistry. Kalimantacin A, isolated from Pseudomonas jluorescens strain
BCCM_ ID9359, is biosynthesised by a trans-AT type I polyketide synthase (PKS) and
exhibits strong and selective activity against multi-resistant Staphylococcus aureus
(MRSA). Two mutant strains, ~batF and ~batM, have been produced from which 17-
hydroxy analogue 20, 27-descarbamoyl analogue 21 and 17-hydroxy-27-descarbamoyl
analogue 22 were isolated and fully characterised.
|
|||||
Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.685333 | DOI: | Not available | ||
Share: |