The initial composition of acrylic bone cement along with the mixing and delivery technique can influence cement final properties and therefore clinical success in vivo. The aim of this research was to investigate the predominant factors that affect the efficacious mixing and delivery of acrylic bone cement, using a pre-filled mixing and delivery system. Using such a system would eliminate the operator dependant issues associated with current commercial systems, and allow control over final properties through altering the chemical composition of the initial constituents. As range of experimental.methods were used to analyse the resultant cement throughout the research. The properties of ISO 5833:2002 were of significant importance as this governs the clinical viability of the cement produced. Results highlighted that is was possible to alter not only the mixing method but also the levels of initial cement constituents, and produced cement that adhered to the requirements of ISO 5833:2002. A key finding was the impact of the initiation chemistry on the properties of the resultant cement, both as independent and interdependent factors. Investigating powder - liquid interactions during the mixing process was of high importance, emphasising the effect of both powder bed packing density and particle size on the ability to achieve a homogenous cement mix. A comparison of mixing systems indicated that removing operator dependency form the process enhanced the predictability of the fatigue performance, a vital characteristic in determining the long term survival of implants. Finally, cement properties versus shelf-life were investigated, highlighting spontaneous polymerisation occurs within the mixing system, during the storage period. The effect of this could led to complications during the surgical procedure, an adverse effect when considering the success of the joint replacement and quality of life for the patient.