Objective: This cross-sectional study aimed to explore predictors of resilience in 12-16 years old with a cleft lip and/or palate. Methods: Adolescents (n=126) were recruited via a regional cleft service and an online support group. The relationships between self-reported resilience (Connor-Davidson Resilience Scale) and peer relationships and experiences (Childhood Experience Questionnaire), family competence (Self-report Family Inventory-II), satisfaction with appearance (Satisfaction With Appearance questionnaire) and coping strategy use (KidCope) were explored. Results: In multiple regression analysis, peer relationships and experiences (β =.33, p < .01), family competence (β =-.23, p < .01) and satisfaction with appearance (β =.20, p < .05) were significantly associated with resilience. Negative coping strategy use was negatively correlated with resilience; however, it was not included in the final regression model. Conclusions: Clinical intervention should focus on developing peer and family relationships and addressing appearance-related cognitions. The need for additional research and evaluation of resilience-enhancing interventions generally, and within this population, is highlighted.