Factors which influence uptake and impact of research • findings from Northern Ireland Health and Social Care System. Tile Payback Framework provides a model by which the totality of impact from specific research or research programmes can be categorized within six domains; Knowledge production, research in the research system, informing policy and decision making, behavioural change, factors influencing utilisation and health service economic benefits. I have utilised the framework to study factors influencing Payback from research completed within the Belfast Trust (2004 - 2007). A web-based survey of 132 projects was conducted, and Payback from individual projects was scored using a simple scoring system previously employed in a study of Payback in Hong Kong and an additional novel Conceptual Equivalent Scale based on pre-defined descriptors of achievement in each of the Payback domains. A purposive sample of six projects was selected for detailed case study analysis of factors Influencing Payback, explored with key project informants. A realist approach was adopted to identify key learning points transferable to research funders and host organisations. Availability of funding, protected time following project completion to allow knowledge transfer and multidisciplinary engagement were key factors identified which influenced Payback across domains.