Title:
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Manufacture and characterisation of bioresorbable fibre reinforced composite bone plates
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This work was motivated initially by the desire to develop fully bioresorbable
bone plates for fracture fixation applications, in order to meet a clinical need.
The purpose of the development is to avoid medical complications related to
rigid, non-resorbable metallic bone plates. Phosphate based glass fibre
reinforced poly-lactic acid (PGF/PLA) composites containing fully
biodegradable and biocompatible constituents can be an effective alternative to
metallic bone plates.
Appropriate design and manufacture of the PGF IPLA composite bone plates is
crucial to ensure that the required mechanical and degradation properties are
achieved for the support of bone healing. Rather than considering simply the
material propelties of the PGF/PLA composites, it is necessary to take into
account all the factors relating to surgical use: constrained plate dimensions,
bone topography and contact area, fixation method, sterilisation method, local
environment and overall nature of the loading case. Each of these factors will
have a profound effect on the design of the composite.
In this PhD, studies have been undertaken to develop and produce a PGF/PLA
composite bone plate that can fulfil the requirements of a specific application.
The composite plates were prepared by using an optimal combination of
unidirectional and random fibre reinforcement, before being trimmed and
drilled into a desired final geometry. To validate the composite design,
mechanical and degradation properties, in vitro mechanical and biomechanical
testing were combined with preclinical in vivo testing using an intact rabbit
tibia bone model.
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