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Title: Proton magnetic resonance spectroscopic imaging of the human brain
Author: Wild, James Michael
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1998
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Over the last ten years proton NMR spectroscopy has been performed on clinical MRI scanners using single voxel localisation and spectroscopic imaging sequences. In this work inner volume excitation of a transverse imaging plane within the brain has been used to obtain single slice spectroscopic images of proton metabolites. The existing image processing protocols used to construct the metabolite images were improved and optimised so as to give as accurate a picture of metabolite distribution as possible. Inaccuracy in these images can be introduced by the excitation profile of the radio frequency pulses used in inner volume excitation. A new normalisation technique is proposed which will remove these inaccuracies enabling more reliable quantification of metabolite concentrations. Of particular importance in stroke is the metabolite lactate, elevated levels of which are symptomatic with the conditions of anaerobic glycolysis that are thought to precede infarction. The signal from lactate is often obscured by lipid and macro-molecule resonances in the same frequency range. Lactate editing sequences compatible with the hardware capabilities of the scanner and spectroscopic imaging sequences were investigated for viability in-vivo. Using two different editing sequences lactate editing was performed successfully in vitro and in vivo. In-vivo results are presented from a study of 40 stroke patients and a smaller pilot study of 8 head injury patients. These patients were drawn from the Lothian Stroke Register as part of the Clinical Research Initiative (CRI) in stroke and head injury being co-ordinated at the Western General Hospital, Edinburgh. To our knowledge this is the largest proton spectroscopic study of acute stroke patients and as such should have a significant bearing in analysing the physiological implications of the disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available