AIMS: To explore the potential presence and the experience of EDs in female IBS patients, and to examine GI nurses’ perception and knowledge of each condition. STUDY DESIGN: A cross-sectional multimethod design integrating two phases was selected. The first and quantitative part of the study encompassed the completion of two EDs screening tools and a battery of questionnaires by 134 patients, seeking to evaluate participants’ symptoms, HRQoL, and general well being. From this population, 25 interviews were conducted in order to explore the participants’ experiences and their views on GI symptoms. 91 GI nurses completed a questionnaire on attitudes and perceptions towards IBS and EDs patients. RESULTS: Screening tools proved helpful in the GI setting to identify potential EDs among female patients with IBS. SCOFF tool highlighted a 24.6 % of the study population as potential cases, appearing as the tool of choice. Quantitative analysis highlighted statistically significant (p<0.01) impairment of HRQoL for the study participants, this impact was particularly noted in those individuals identified as potential EDs cases. Emerging themes from the qualitative data underlined the complexity of the individual patient’s journey, and the variety of strategies adopted to comprehend and manage their condition. Suffering, social isolation, unmet support needs and lack of control appeared inherent to the condition. Results suggested that diet and modifying eating habits can be used as a management strategy to control IBS symptoms. The need for nurses’ further education and training regarding IBS and EDs was highlighted by the study findings. CONCLUSIONS: This study gives strong support to the suggestion of IBS and EDs comorbidity, through the specific incidence is yet to be determined.