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Title: Factors affecting the composition of body fluids in maternal, fetal and neonatal goats and sheep
Author: Pearson, R. A.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1977
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Factors affecting the composition of plasma, amniotic fluid, allantoic fluid, fetal urine and fetal ruminal and abomasal fluid were studied. Effects of laboratory conditions and experimental procedures on plasma composition were examined in goats and sheep. It took animals 1-2 weeks to adapt to the laboratory and 3-6 weeks of handling to adjust to prolonged procedures such as repeated venepuncture. Surgical insertion of uterine catheters was associated with changes in feed intake and plasma composition which were present after operation for up to seven days in sheep and 12 days in goats. Gestational changes in fetal fluid composition were examined in goats. Amniotic fluid composition was similar to that in sheep but differences in allantoic fluid composition were observed. It was not possible to say whether these differences were related to species differences in hormone production. during pregnancy because exogenous progesterone was given in an attempt to reduce the high incidence of postoperative abortion encountered in goats. Gestational changes in the composition of ruminal and abomasal fluid were studied in sheep. Values for sodium and potassium concentrations and osmolality of the amniotic, ruminal and abomasal fluids suggested that amniotic fluid was modified during its passage between the amniotic sac and the rumen. Effects of fetal adrenocorticotrophin and corticosterone infusion on the composition of allantoic fluid and fetal urine were studied in sheep. Results were consistent with an hypothesis that fetal corticosteroids act on ion pumps in the chorioallantois and fetal kidneys to alter the sodium and potassium concentrations of allantoic fluid and fetal urine. Changes in blood composition during the first 12 hours of life were observed in lambs and kids using a non-surgical method of catheterising the aortas and venae cava. Marked changes in composition occurred as breathing was established and after sucking. Effects of hypothermia and haemorrhage on blood composition were also reported. Finally, the 'chronic' approach to fetal physiology was critically evaluated. In this work the term 'chronic' has been used to describe the continuous study of conscious, catheterised animals.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available