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Title: Characterisation of host determinants that influence host-pathogen interaction during infection with Mycobacterium tuberculosis
Author: Kreutzfeldt, Kaj Maximiliane
ISNI:       0000 0004 5359 587X
Awarding Body: University of Brighton
Current Institution: University of Brighton
Date of Award: 2015
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Tuberculosis is endemic in the Gambian population, in which the magnitude of mycobacterial antigen-driven interferon-γ (IFN-γ) response in BCG vaccinated neonates has been linked to regions on the genome that encode the RIP2 kinase, the toll-like receptor 4 adapter protein MD-2 and the NF-κB subunit NF-κB2 by genome-wide linkage analysis. The receptor interacting protein (RIP2) is an essential kinase downstream of the nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2, both intracellular pattern-recognition receptors for peptidoglycan moieties that induce activation of NF-κB. To establish the significance of RIP2 kinase during Mycobacterium tuberculosis infection, RIP2 was depleted in THP-1- derived macrophages using small interfering RNAs. In the absence of RIP2, THP- 1-derived macrophages secreted significantly reduced levels of the proinflammatory cytokine IL-1β upon infection with M. tuberculosis.
Supervisor: Not available Sponsor: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: A000 Medicine