A brief note has been given of the earlier work on genito-urinary tuberculosis and its diagnosis by specialised methods. The etiology and pathology of the disease has been discussed at some length. It is maintained that only by an accurate knowledge of the genesis of tuberculosis can we hope to be successful in our treatment. The clinical manifestations described are based on personal observations made over a period of twenty-six years. Recent methods of diagnosis are mentioned. A brief outline is given of treatment particularly in regard to the giving of tuberculin, and a plea is put forward for its more extensive use in the disease. The relationship of surgery to genito-urinary tuberculosis is discussed.