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Title: Studies of Theileria parva related to the salivary glands of the vector tick
Author: Martins, Maria Isabel F. C.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1977
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A histological and histochemical study of the relationship between the protozoan Theileria ap rva and the salivary gland cells of its natural vector, the tick Rhipicephalus appendiculatus has been made. The literature relating to this subject is reviewed. As a basis for examining the possibility of host cell participation in the development of the parasite, the changes that occur in non-infected glands with the process of feeding were first examined and results compared with those obtained with T. parva. infected glands. The possible function of the different acinar cells is presented. Three types of acini were described in the female and four in the male. The morphological features of the cell types described here correspond to those presented by Till (1961) with the exception of those of Type IV in males which showed secretory granules in unfed ticks. The most likely function of non-granular cells forming Acinus, in both sexes of R. appendiculatus, is in the ionic balance of the tick haemolymph. In Types II and III acini, cells (a), (c) and (d) are considered to secrete cement precursors and a proteolytic enzyme while (b) cells have a general role in the process of feeding. In feeding females, Type (e) cells are thought to be responsible for water secretion. In feeding males, Types (f) and (g) cells are possibly related to reproduction. The association between Theileria parva and the salivary gland cells of the vector seems to be parasitic rather than symbiotic. Morphological changes observed in the host cell nucleus were associated with loss of nucleic acid material and a reduction in acid phosphatase activity. In the host cell cytoplasm, infection was characterised by an increase of reaction for oxido-reductases and PAS positive material and a disappearance of acid phosphatase and of the tyrosine-rich secretory granules. Possible metabolic pathways followed by T. parva in the process of maturation are indicated and an ultrastructural study of forms of the parasite in the salivary glands of unfed and feeding ticks presented.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available