The advent of wireless location technology and the increase in location-based services, has meant the need to investigate efficient network-based location methods becoming of paramount importance. Therefore, the interest in wireless positioning techniques has been increasing over recent decades. Among mobile positioning techniques, the Time of Arrival (TOA) and Time Difference of Arrival (TDOA) look promising. For the purpose of dealing with such technologies, some classic algorithms such as least square, most likelihood and Taylor method have been used to solve the estimation, which distinguishes the location. However, in real practice, there are certain factors that influence the level of location accuracy. The two most significant factors are cellular topologies and non-line-of-sight (NLOS) effect. This thesis reviews existing approaches and suggests innovative methods for both line-of-sight (LOS) and NLOS scenarios. A simulation platform is designed to test and compare the performances of these algorithms. The results of the simulation compared with actual position measurements demonstrate that the innovative approaches have high positioning accuracy. Additionally, this thesis demonstrates different types of cellular topologies and develops a simulation to show how the cellular topology affects the positioning quality level. Finally, this thesis implements an experiment to exhibit how the innovative algorithms perform in the real world.