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Title: Observations on the treatment of malaria by combined plasmoquine and quinine method
Author: Khan, Fateh Mohammd
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1931
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(i) The combined plasmoquine and quinine treatment is definitely superior to simple quinine treatment in the following respects: - (a) In producing a definite reduction in the duration of the temperature in the individual. (b) In the destruction of gametocytes especially in the case of M.T. infection where it has a definite effect but not to the extent claimed by the manufacturers. (ii) No appreciable advantage can be claimed by this treatment in the reduction of splenic enlargement. (iii) Toxic symptoms were manifested in 10.7% of cases treated and appeared after the administration of an average dose of 0.12 gram approximately. The majority of these cases showed these symptoms after 48 hours of administration. (iv) Toxic symptoms noted are Gastralgia, abdominal pain, vomiting, diarrhoea, dysenteric symptoms, cyanosis and paleness of the skin and general discomfort. (v) Cyanosis or methaemoglobinaemia was not noticed in these cases as by other observers, as all the cases which were treated have dark skins, and lesser degrees of cyanosis cannot be detected without spectroscopic blood examinations which were not carried out. (vi) The toxic effects of plasmoquine require careful watching and medical supervision is at all times indispensable. Dosage recommended 0.02 gram, twice a day for twenty -one days seems to be a safe one. (vii) The provocative effect of plasmoquine in case of double infection has not been proved. (viii) Prophylactic use of plasmoquine as a routine antimalarial measure is not advisable. (ix) Considering all these points it is not desirable to recommend this method of treatment as a universal routine measure, but with proper safeguard this treatment may be adopted in B.T. infection and in the cases of crescents.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available