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Title: The metabolism of ascorbic acid in rheumatoid arthritis
Author: Forshall, William
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1958
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(1) It has been confirmed that rheumatoid arthritis patients have a lower plasma level and a lower urinary excretion of ascorbic acid than non -rheumatoid controls receiving the same intake of ascorbic acid. (2) It has been shown that these patients require a longer time to reach saturation with the vitamin, on a standard daily dose, than control subjects. (3) It has been shown also that rheumatoid arthritis patients have a lower level of ascorbic acid in the leucocytes, a higher dehydroascorbic acid concentration in the plasma and a higher ascorbic acid concentration in the erythrocytes than do normal subjects on the same dietary intake. (4) Patients with rheumatoid arthritis excrete less oxalic acid than do non -rheumatoid controls and show a smaller increase in excretion of oxalic acid after a large intravenous dose of ascorbic acid. (5) The implication of these findings has been discussed and points requiring further investigation have been suggested.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available