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Title: Oxygen uptake kinetics at the onset of exercise and cardiorespiratory fitness in frail elderly people
Author: Fitzsimons, Claire Frances
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2006
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Methods: VO2 and walking speed were measured during 3 minutes of comfortable self-paced walking in young (Y) (N=17, median age 23 (20-29) years) and healthy elderly (HE) (N=15; median age 80 (76-87) years) volunteers and groups of patients recovering from a hip fracture (HF) (N=8; median age 81 (72-91) years) or stroke (ST) (N=66; median age 74 (49-87) years). Results: Feasibility. On 214/277 study visits individuals completed 3 walks of 3 minutes (77%). Participants maintained a constant walking speed of moderate intensity and achieved steady state VO2 ­conditions within 3 minutes on 127/214 visits. 114/127 visits (41% of 277) were adequately described using a monoexponential model (82% Y; 44% HE; 53% HF; 32% ST). Validity: A group comparison of MRT demonstrated content validity (Y 20s; HE 37s; HF 52s; ST 42s, mean values, visit 1). Criterion-related concurrent validity (MRT versus VO2 max, in Y and HE) and predictive validity of MRT were not demonstrated. Reproducibility: The Standard Error of Measurement (SEM) of the MRT was 4.9s in the Y group, 4.4s in the HE group and 7.0s for the HF group. Limits of agreement of MRT for the HF group were -23 to 30s. Training intervention: Poor tolerance of the study methodology in the frailer stroke patients compromised evaluation of the training intervention. A before and after training comparison of MRT was possible in 4 stroke patients.  A training related reduction in MRT (49s to 35s (mean values, N=4)) was evident. Conclusion: The inability of frailer study participants to achieve feasibility criteria and inconclusive validity questions the applicability of this measure to those for whom it is intended – very frail, older people.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available