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Title: The child of the diabetic woman
Author: Farquhar, James W.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1958
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Abstract:
This thesis consists of personal observations made upon 96 children of diabetic women from their intrauterine life up to the age of ten years, and of information about their mothers and their siblings. The curious morphology shared by the infants of pre - diabetic and diabetic women includes foetal overgrowth, pancreatic islet hyperplasia, extramedullary haemopoiesis and possible adrenal enlargement. The principal autopsy finding, in neonatal deaths is pulmonary hyaline membrane. Animal experiments and the observations of others on these babies suggest that the morphology is due to an anterior pituitary disorder and to an excess of Pituitary Growth Hormone in particular. The personal observations in this series suggest that the morphology results from the action of a aternal diabetogenic growth factor, to which the influence of adrenal corticosteroids, and later of hyperglycaemia, may e added. Neither the growth factor nor the hyperglycaemia appear to be the principal causes of foetal death, but the utter probably contributes to it. Failure of placental function is probably responsible or intra-uterine death, for interference with growth stimuation, and for the hypoxia which, with the perinatal circuatory changes, is responsible for much of the neonatal orbidity and mortality. The premature placental failure occurs in many, but not in all, pre -diabetic and diabetic women, and it may be caused by adrenal corticosteroids. The laboratory studies which form part of this thesis establish the normal range of the blood sugar level during each of the first ten days of life and prove that the hypoglycaemia, which occurs so commonly in infants of diabetic omen, is not responsible for the neonatal clinical disturance and that it does not cause irreversible cerebral damage. They also suggest that increased adrenocortical activity exists in the foetus. Important congenital malformations occur no more commonly in these babies than they do in children of non -diabetic women, and no significant difference in growth or in the incidence of diabetes mellitus has been noted up to the age of ten years. Further observations of such a group over a period of twenty years or more will probably be necessary before the risk of such children becoming diabetic can be fully assessed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.650502  DOI: Not available
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