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Title: Tissue manipulation using nano-particles ferrofluids for minimal access surgical applications
Author: Lin, Yu-Sheng
ISNI:       0000 0004 5357 8746
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2014
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Nano-scale Iron-Oxide ferrofluids exhibit a special property, ‘superparamagnetism’, that induces an attractive force toward an external magnetic field. The aim of this project is to investigate the use of ferrofluids for tissue retraction during Minimally Access Surgery (MAS). In the in-vivo porcine experiments, 0.3 ml of ferrofluid (200 mg/ml concentration) containing 10 nm particles is injected subserosally into the small bowel, respectively. A 0.6 T magnetic field is created using a combination of 10 mm and 20 mm diameter Neodymium Iron Boron magnets. The vertical retraction distance is measured up to 80 mm and video-recorded. The results demonstrate the capacity of ferrofluid to facilitate the tissue manipulation and analysis of the migration of the particles within the tissue using micro computed tomography (CT). A theoretical model developed to validate the experimental results is also beneficial for predicting retraction force. In conclusion, this feasibility study provides a protocol for systematically using small volumes of ferrofluid, without the need to mechanically grasp the tissue.
Supervisor: Neville, Anne ; Liskiewicz, Tomasz ; Roshan, Rupesh Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available