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Title: Functional & molecular analysis of Bod1 in mitotic chromosome segregation
Author: Schleicher, Katharina
ISNI:       0000 0004 5353 0099
Awarding Body: University of Dundee
Current Institution: University of Dundee
Date of Award: 2014
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Preservation of genetic integrity during mitotic chromosome segregation requires the attachment of sister chromatids to microtubules emanating from opposite poles of the mitotic spindle. Successful mitosis and cell cycle progression critically depend on the achievement of this attachment state, otherwise called amphitelic attachment or biorientation. Cells therefore operate an error‐correcting system at the kinetochore, which is the main microtubule attachment site on chromosomes. This system selectively removes incorrect attachments while leaving amphitelic attachments unaltered. Error correction of microtubule attachments heavily depends on integration of kinase‐phosphatase signalling. The data presented in this thesis suggest that one mechanism of fine‐tuning this phospho‐regulation at the kinetochore is the regulation of protein phosphatase 2A (PP2A) by the small kinetochore protein Biorientation defective 1 (Bod1).
Supervisor: Swedlow, Jason Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available