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Title: Denture stomatitis : clinical and laboratory studies
Author: Bissell, Vincent
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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This thesis describes investigations conducted to study factors influencing the outcome of antifungal treatment of denture stomatitis. Clinical, mycolognic, haematologic and prosthodontic factors were evaluated. The humoral and cellular immune responses were also studied. Two antifungal agents were compared: systematically administered fluconazole and topically administered amphotericin. A total of 29 patients were randomised to receive fluconazole 50mg daily for 14 days; 30 were randomised to receive amphotericin lozenges and cream for 28 days. Patients were assessed at the time of entry into the study and at one, four and twelve weeks thereafter. There were no significant differences in clinical response between the groups at any follow-up visit. The best clinical response was observed after four weeks whereas the best mycologic response was noted after one week. At the 12 week assessment clinical evidence of relapse and recurrence was a common finding irrespective of treatment. Overall the correlation between mycologic and clinical events was poor. Correlation was better in those patients who demonstrated very poor and very good clinical responses. Fluconazole appeared to be largely ineffective against Candida glabrata. Haematologic deficiencies were infrequent and appeared not to affect clinical outcome. Clinical response in non-smokers was better than in smokers and this difference was significant at the one week visit. Denture quality although generally poor appeared to exert no marked influence over clinical outcome. Adverse reactions to treatment were uncommon in both groups. Little change was observed in serum and salivary total and anti-candidal antibodies throughout the study. However the humoral immune response in smokers appeared to be depressed in comparison with non-smokers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available