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Title: Templated interlocked host structures for the recognition and sensing of charged substrates
Author: Knighton, Richard C.
ISNI:       0000 0004 5366 3502
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2014
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This thesis describes the synthesis of acyclic, macrocyclic and, in particular, interlocked anion and ion-pair receptors and sensors. Chapter One will introduce the field of supramolecular chemistry with particular emphasis on areas which are pertinent to this thesis, including anion receptor design and templated synthesis of interlocked structures. Chapter Two focuses on the synthesis of new heteroditopic macrocycles functionalised with both cation and anion recognition sites and their incorporation into interlocked architectures. The affinity for a range of anions and ion-pairs is explored via 1H NMR and UV-visible spectroscopy as well as by X-ray crystallography. Chapter Three details the incorporation of d- and f-metal luminescent reporter groups into an isophthalamide motif in order to construct acyclic, macrocyclic and [2]rotaxane receptors. Chapter Four investigates the synthesis of complex higher-order interlocked structures through post-synthetic modification of lower-order interlocked structures. Chapter Five explores the potential for fluorescent gold nanoparticle conjugates to act as luminescent and colourimetric sensors for chemical warfare agents (CWAs) by employing a fluorescent displacement assay technique.
Supervisor: Beer, Paul D. Sponsor: Engineering and Physical Sciences Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Supramolecular chemistry ; anion ; sensing ; rotaxane ; catenane