Use this URL to cite or link to this record in EThOS:
Title: The involvement of lymphatics in colorectal cancer
Author: Smith, Katherine Jan Elizabeth
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2013
Availability of Full Text:
Access from EThOS:
The spread of cancer to lymph nodes is one of the most important prognostic factors across all human malignancies. This spread is via lymphatic vessels that collect debris from peritumoral areas and carry it to the lymph nodes where cancer can then grow into secondary deposits. Despite the potential prognostic importance of these lymphatic vessels, accurate means to identify and quantify them in colorectal tissue has not been available until recently. The aim of this thesis was to develop the methods to utilise a new sensitive and specific lymphatic endothelial marker, D2-40, to identify and quantify lymphatic vessels in colorectal tissue. We hypothesised that the lymphatic density in normal superficial colorectal wall could explain why the risk of nodal spread in early tumours increases as invasion into deeper submucosal layers occurs. We also planned to identify associations between increased lymphatic density in or around a Dukes' B tumour and a reduction in survival or other poor prognostic factors in the Dukes' B category. We demonstrated that lymphatic vessel density was significantly higher in the most superficial layer of the submucosa with no significant increase in size as they descend into the deeper layers. This suggests the amount of tumour in the superficial layer maybe the more important factor when considering risk of nodal spread as here it is exposed to higher numbers of lymphatic vessels which it could subsequently invade.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available